Oxymatrine e sebelisetsoa eng?
2023-12-11 14:38:50
Oxymatrine phofo ke setlama sa litlama se tsoang motsong oa Sophora flavescens, semela se tloaelehileng meriana ea setso ea Machaena (TCM). Oxymatrine e 'nile ea sebelisoa ho phekola Chaena ka lilemo tse ka bang 2,000 bakeng sa melemo ea eona e pharaletseng ea phekolo (1).
Lilemong tse mashome tsa morao tjena, oxymatrine e hohetse thahasello e ntseng e eketseha ho tsoa meriana ea Bophirimela ka lebaka la lipatlisiso tsa saense tse hlahang tse netefatsang boholo ba mekhoa ea eona ea phekolo ea setso. Liphuputso li bontša hore oxymatrine e ka thusa ho loantša kankere, tšoaetso ea kokoana-hloko, ho ruruha, ho kula, le tse ling (2).
Joale oxymatrine e sebelisetsoa eng ha ho tluoa tabeng ea bophelo bo botle le pholiso? Mona ke kakaretso ea lipatlisiso tsa morao-rao tsa mahlale tse amanang le ts'ebeliso e ngata ea bongaka ea oxymatrine.
1. 
Ho Loantša Kankere le Lihlahala
Palo e kholo ea lipatlisiso tsa morao-rao e tsepamisitse maikutlo ho matla a oxymatrine a khahlanong le mofetše, ka lithuto tse fetang 180 lilemong tse leshome tse fetileng. Lithuto tsa in vitro le liphoofolo li bonts'a oxymatrine e ka thibela kholo, ho falla, tlhaselo le metastasis ea mefuta e mengata ea lisele tsa mofetše (3).
Lik'hemik'hale tse khethehileng moo oxymatrine e bonts'ang bokhoni ba anti-tumor e kenyelletsa:
- Kankere ea pancreatic: Oxymatrine e ile ea bontšoa ho susumetsa apoptosis le ho ts'oaroa ha cell cycle (4).
- Kankere ea matsoele: Oxymatrine e ka hlola ho hanyetsa lithethefatsi le ho hanyetsa mahlaseli (5).
- Kankere ea Colon: Motsoako o hatelletse ho ata ha lisele tsa mofetše oa colon le ho baka lefu le hlophisitsoeng la lisele (6).
Kankere ea sebete: Oxymatrine e bonts'a cytotoxicity ho lisele tsa carcinoma tsa hepatocellular (7).
- Kankere ea matšoafo: Liphuputso li bonts'a motsoako o thibelang ho falla, tlhaselo le phetoho ea epithelial-mesenchymal
ea lisele (8).
Mekhoa e khahlanong le mofets'e ka morao ho oxymatrine e na le merero e mengata le e rarahaneng. Empa ha e le hantle, tlhahiso
e laola maemo a liphatsa tsa lefutso mme e fetola litsela tsa bohlokoa tsa matšoao ka har'a lisele tsa mofetše, ho li thibela
ho hōla le ho ata (2).
Le hoja lipatlisiso tse ngata e ntse e le tsa pele, oxymatrine e bontša tšepiso e kholo e le phekolo e kopanetsoeng
haufi le sebete se tloaelehileng, sefuba, mala, matšoafo, manyeme le liphekolo tse ling tsa mofetše.
2. Ho Loantša Likokoana-hloko
Oxymatrine e bonts'a ts'ebetso e pharalletseng ea antiviral khahlano le mefuta e mengata ea livaerase ka mekhoa e mengata. E bolaea ka ho toba lisele tsa kokoana-hloko, e thibela ho ikatisa ha kokoana-hloko, 'me e matlafatsa tšireletso khahlanong le likokoana-hloko.
Livaerase tse khethehileng tsa oxymatrine li bonts'a katleho khahlano le ho kenyelletsa:
- Kokoana-hloko ea Hepatitis B (HBV): Oxymatrine e hatelletse HBV replication in vitro le ho ntlafatsa matšoao a hepatitis B hammoho le phekolo e tloaelehileng ea lithethefatsi lithutong tsa batho.
- Coxsackievirus B3 (CVB3): Oxymatrine e sirelelitsoe khahlanong le myocarditis le kotsi ea pelo ho tsoa ho tšoaetso ea kokoana-hloko ho litoeba.
- Livaerase tsa ho hema: Lithuto tsa tube ea liteko li fumane hore oxymatrine e na le litlamorao tsa antiviral ho parainfluenza, RSV, le livaerase tse 'maloa tsa ntaramane.
- Herpes simplex virus (HSV): Topical oxymatrine folisa maqeba a letlalo ho tloha HSV-1 ka mohlala oa liphoofolo.
- HIV: Leha liphuputso li lekanyelitsoe, phuputso e 'ngoe e bontšitse hore oxymatrine e ka thibela ho ata ha HIV.
Thepa ea antiviral ea oxymatrine e etsa hore e be molemo bakeng sa mefuta e mengata ea mafu a tšoaetsanoang a vaerase. Liteko tse ling tsa bongaka li ntse li hlokahala, empa bopaki ba hajoale bo netefatsa tšebeliso ea eona ea setso khahlano le lefu la sebete la mofuta oa B hammoho le mafu a mang a vaerase.
3. Ho Laola Mosebetsi oa 'mele oa ho Itšireletsa le ho Fokotsa ho Ruruha
Ho ruruha ho feteletseng ho baka mathata a sejoale-joale a ho ruruha joalo ka lefu la pelo, lefu la tsoekere, ramatiki, lefu la ho ruruha ha mala (IBD), eczema, asthma le tse ling. Oxymatrine e bonahala e laola likarabo tsa 'mele tsa ho itšireletsa mafung tse tsamaisang ho ruruha ho sa hlokahaleng.
Lipatlisiso tsa liphoofolo li fumane hore oxymatrine e fokolitse ho ruruha ka katleho mefuteng ea:
- Pancreatitis: E sirelelitsoe khahlanong le tšenyo ea ho ruruha le kotsi ea lisele tsa pancreatic.
- Leqeba la pelo: Ho fokotseha hoa ho ruruha ha myocardial ho tloha ho ischemia-reperfusion.
- Ho lemala sebeteng: Ho kokobetsa lefu la sebete la ho ruruha ho litoeba.
- Kotsi ea matšoafo: Tšenyo e fokotsehileng ea ho ruruha le ho tsosolosa sebopeho sa alveolar ka mor'a ho nyelisoa.
- Ho ruruha ha liphio: Ho thibela haholo ho lokolloa ha cytokine sebakeng seo le tšenyo ea lisele.
- Ho ruruha ha letlalo: Litlolo tsa Oxymatrine li kokobelitse ho ruruha mefuteng ea eczema.
Litlamorao tse khahlanong le ho ruruha tsa oxymatrine li kanna tsa bakoa ke ho thibela li-cytokine tse ling tsa pro-inflammatory,
ts'ebetso ea lisele tsa 'mele oa ho itšireletsa mafung, pontšo ea NF-κB le tse ling.
Ka ho khutsisa karabelo e feteletseng ea 'mele ea ho itšireletsa mafung, oxymatrine e bonts'a ts'episo ea ho laola ts'oaetso ea sejoale-joale
mathata. Bokhoni ba eona ba ho fetola 'mele oa ho itšireletsa mafung bo ka boela ba thusa ho loantša ho kula le asthma.
4. Ho Sireletsa Bophelo bo Botle ba Sebete
Sebete se ntša chefo maling, se ntša limatlafatsi, se ntša bile, 'me se etsa mesebetsi e meng ea bohlokoa e amanang le tšilo ea lijo le metabolism. Oxymatrine e 'nile ea sebelisoa ka tloaelo ho phekola mathata a sebete' me lipatlisiso tsa morao-rao li tiisa liphello tse matla tsa hepatoprotective.
Lithutong tsa batho le liphoofolo, oxymatrine:
- E sireletsa lisele tsa sebete tšenyong ea chefo ea lik'hemik'hale.
- E thibela nts'etsopele ea fibrosis le cirrhosis.
- E thusa ho hlaphoheloa ha sebete ho bakuli ba lefu la sebete.
- E fokotsa mafura a sebete a bakoang ke tai, lijo tse sa jeng hantle kapa lefu la tsoekere.
Mekhoa e ka morao ea liphello tsa eona tse molemo ho bophelo bo botle ba sebete e na le mefuta e mengata. 98% Oxymatrine e bonts'a bokhoni bo tobileng ba antioxidant, e ntlafatsa ts'ebetso ea li-enzyme tsa antioxidant ea sebete, e fokotsa apoptosis ea lisele tsa sebete, e sireletsa mitochondria le tse ling.
Lipatlisiso li tšehetsa ka ho hlaka tšebeliso ea setso ea li-supplement tsa oxymatrine ho ntlafatsa bophelo bo botle ba sebete, ho phekola maloetse, le ho thibela tšenyo e bakoang ke chefo kapa meriana.
Nomoro ea CAS ea Oxymatrine ke eng?
Nomoro ea ngoliso ea CAS, eo hape e tsejoang e le nomoro ea CAS kapa CAS RN, ke sesupo sa linomoro se ikhethileng se abeloang ntho e 'ngoe le e 'ngoe ea lik'hemik'hale e hlalositsoeng libukeng tsa mahlale. CAS e emetse Chemical Abstracts Service, mokhatlo o laolang polokelo ea lintho tsa lik'hemik'hale 'me o abela liitlhahiso tsena. Ngoliso ea CAS hona joale e na le lintho tse fetang limilione tse 154 tsa tlhaho le tse sa sebetseng le liprotheine tse fetang limilione tse 80 le tatelano ea DNA.
Bakeng sa oxymatrine, nomoro ea CAS ke 16837-52-8. Nomoro ena e ikhethang, e ikhethang e supa ka mokhoa o hlakileng oxymatrine har'a leoatle la lik'hemik'hale tse fetang limilione tse 154 tseo hajoale li nang le linomoro tsa CAS. Nomoro ea CAS 16837-52-8 e ka sebelisoa ho batla li-database le lingoliloeng tsa saense ho fumana tlhahisoleseling ka ho khetheha ka oxymatrine ho fapana le tse ling tse tsoang ho matrine kapa mabitso a lik'hemik'hale a tšoanang a ferekanyang.
Summary
Ho ea ka lipatlisiso tsa morao-rao tsa saense hammoho le lilemo tse ka bang 2,000 tsa tšebeliso ea setso Chaena, oxymatrine e na le melemo e mengata ea phekolo:
- Matla a khahlanong le mofetše le anti-tumor khahlano le sebete, mala, matsoele, pancreatic le mefuta e meng ea mofetše.
- Litlamorao tsa antiviral khahlano le hepatitis B, kokoana-hloko ea coxsackie B, herpes, le tse ling.
- Lintho tse laolang 'mele le tse thibelang ho ruruha tse ka thusang maemo a autoimmune.
- E sireletsa sebete ho chefo, livaerase, mafura a mangata le likotsi.
Lisebelisoa tse ling tse nyane bakeng sa oxymatrine li kenyelletsa ho thibela arrhythmia ea pelo, ho fokotsa bohloko, ho loantša li-fungus le libaktheria, ho sireletsa liphio, ho ntlafatsa mathata a mala, le tse ling.
Oxymatrine e lokeloa ke tlhahlobo e eketsehileng ea kliniki ho netefatsa lits'ebetso tsa kalafo. Empa ho fihlela joale, liphuputso li totobatsa bohlokoa bo boholo ba moriana ona. Li-supplement tsa Oxymatrine ka letsatsi le leng li ka fumana ts'ebeliso e tloaelehileng hammoho le liprothokholo tsa ngaka, lefu la sebete, ramatiki le mafu a mang a mangata a bakoang ke ho ruruha.
WELLGREEN ke moetsi ea khannoang ke boqapi ba litlama ho tloha ka 2011 tse netefalitsoeng ke ISO9001:2015, ISO22000, HALAL, KOSHER, HACCP, le Setifikeiti sa Organic. Haeba u hloka Oxymatrine phofo, ka kopo ikopanye le rona hang-hang, E-mail:wgt@allwellcn.com Re ka fana ka litšebeletso tse ikhethileng ho latela kopo ea hau.
References:
1. Lu YF, Wan J, Liu Y, Qi DW. Tokisetso le katleho ea analgesic ea oxymatrine microemulsion. Biol Pharm Bull. 2012;35(9):1528-32.
2. Gao JL, Shi FD, Li ZH, et al. Tsoelo-pele ea mesebetsi ea meriana le mekhoa ea oxymatrine. Pharmazie. 2020;75(11):467-476.
3. Lu Y, Li CS, Qian LJ, et al. Oxymatrine e etsa hore motho a be le kankere ea pancreatic ea motho PANC-1 lisele tse apoptosis ka ho laola polelo ea malapa a Bcl-2 le IAP, le ho lokolloa ha cytochrome C. Journal of Experimental & Clinical Cancer Research. 2011;30:66.
4. Zhao XL, Wei L, Shi X, et al. Oxymatrine e kenya apoptosis mme e thibela ho ata ha lisele tsa mofetše oa pancreatic ka tsela ea mitochondrial apoptotic. Lefatše J Surg Oncol. 2017;15(1):12.
5. Wu XZ, Chen D. Katleho ea oxymatrine ho phekola kankere. Acta Pharmacol Sin. 2016;37(10):1194-1206.
6. Guo QL, U QD, Wu ZQ, Yuan ST, Zhao L. Thuto e akaretsang ea pharmacological ka liketso tse khahlanong le ho ruruha le tsa analgesic tsa oxymatrine. China Journal of Chinese Materia Medica. 2004;29:32–34
7. Fan J, Wu XZ, Zhang SL, Li XJ, Wang XY, Xiang GL. Oxymatrine e etsa hore lisele li tšoaroe le ho apoptosis 'me li hatelle ho khomarela lisele, ho falla le ho hlasela liseleng tsa hepatocellular carcinoma. Oncol Lett. 2018;15(2):1719-1724.
8. Wu D, Dou J, Gu N, et al. Oxymatrine e thibela kholo ea lisele tsa glioma ka ho ts'oaroa ha cell cycle le apoptosis. Oncol Lett. 2013;5(1):199-203.
9. Gao JL, Shi FD, Li ZH, et al. Tsoelo-pele ea mesebetsi ea meriana le mekhoa ea oxymatrine. Pharmazie. 2020;75(11):467-476.
